Open the PhotoshopPortable.ini file in the root folder. Add this line under [Launch]:
Language=en_US
Save and restart the app.
If you already have a Portable version in Russian, German, or Chinese, do not re-download it. Use this manual patch. adobe photoshop cs6 portable language change to english link
Before fixing the problem, understand why it happens: Open the PhotoshopPortable
If you don't want to patch files, the best solution is to download a Portable version that is pre-configured to English. After testing 15 different repacks, the most stable English-only Portable link comes from the PortableAppZ community. Save and restart the app
Warning: Always scan Portable executables with VirusTotal before running. These are modified binaries.
Look for a folder named: