1.6.5 — Chimera

For completeness, it is worth noting that UCSF Chimera 1.6.5 exists in the field of structural biology.

To maintain compliance with Apple’s security notarization requirements and 64-bit architecture standards, the bundled dependency libraries have been updated:

  • Run the installer – it does not require administrative privileges (can install in your home folder).

    • Warning: Chimera 1.6.5 uses 32-bit binaries on Windows and older OpenGL. It may not run on macOS Catalina (10.15) or newer due to dropped 32-bit support. chimera 1.6.5

    If you work with molecular structures (proteins, DNA, small molecules), you have likely heard of UCSF Chimera. Version 1.6.5 is a specific, stable release that many researchers still use today. While newer versions (like 1.17+) and the successor (ChimeraX) exist, 1.6.5 remains a lightweight, dependable option, especially for older hardware or specific legacy workflows.

    For Windows:

    For macOS:

    brew tap chimera-lang/chimera
brew install chimera@1.6.5

    Alternatively, download the .dmg file and drag Chimera to the Applications folder. For completeness, it is worth noting that UCSF Chimera 1

    For Linux (Debian/Ubuntu):

    wget https://repo.chimera.org/apt/pool/chimera-1.6.5-amd64.deb
sudo dpkg -i chimera-1.6.5-amd64.deb
sudo apt-get install -f

    Installing Chimera 1.6.5 is straightforward, but there are common pitfalls. Follow this guide to ensure a smooth setup: Run the installer – it does not require

    The bootloader components have been synchronized with the mainline OpenZFS logic, improving support for multi-disk boot configurations and enhancing reliability when booting from mirrored pools.