No. The game was officially released only in Japanese (for Japan and Asia regions). There is no official Spanish, English, or European version of K-ON! Hōkago Live!!.
Any mention of "K-ON PSP ISO Español" refers to fan-made Spanish translations (patches or modified ISOs) created by community groups. These are not official and often require patching the original Japanese ISO. k on psp iso espa%C3%B1ol
Un archivo ISO es una imagen exacta de un disco (en este caso, de un UMD de PSP). Contiene todos los datos del juego y se puede cargar desde la tarjeta de memoria con firmware personalizado (custom firmware, CFW) o usando emuladores en otros dispositivos. Hōkago Live
K-ON! Hōkago Live!! is a rhythm game developed by Sega and published in 2010 exclusively for the PSP. Based on the wildly popular anime/manga K-ON!, the game lets players perform as the light music club — Yui, Mio, Ritsu, Tsumugi, and Azusa — playing fan-favorite songs from the series. These are not official and often require patching
The original release was Japan-only, so an English or Spanish version never officially existed. That’s where fan translation patches come in, including a Spanish-language patch released by the fan group Traducciones Cuervo (or similar teams).