The portable edition runs identically to the installed version if your hardware supports DirectX 12 Ultimate and (for ray tracing) an NVIDIA RTX 20 series or newer, or AMD RX 6000+ series.

Potential drawbacks:

The desire for a portable version of Toolbag 501 stems from several professional realities:

Searching for and utilizing "Marmoset Toolbag 501 Portable" carries significant risks, primarily because it is almost certainly an unauthorized modification of the official software.

Using an unauthorized portable version constitutes software piracy.

Given the industry trend (e.g., Adobe’s move to Creative Cloud, Substance Painter’s network licensing), native portable apps are dying. However, WebGPU and cloud streaming may render the portable EXE obsolete.

For now, the most reliable "Marmoset Toolbag 501 portable" experience is a combination of a fast external SSD, a licensed installation, and the Windows-native "Portable Workspace" feature.