This is common on macOS Catalina and newer. The driver is not notarized by Apple.
If you cannot install the driver because your macOS is too new, you must use the keyboard in "MIDI Mode." maudio axiom pro 49 driver mac exclusive
Subject Line: Mac exclusive: No driver? No problem (M-Audio Axiom Pro 49) This is common on macOS Catalina and newer
Recommendation: If you are creating a video for this, focus on the Channel+Zone button combo and show the "USB Audio Device" appearing in Audio MIDI Setup. That is the exclusive "trick" that 90% of users don't know. In your DAW (GarageBand, Ableton, Logic):
Here’s a concise review focused specifically on the M-Audio Axiom Pro 49 driver situation for Mac users (as of 2024–2026).