Sdam-071 -

| Item | Details | |------|---------| | Title | “SDAM‑071: A Potent, Selective, and Brain‑Penetrant Sigma‑1/TMEM97 Modulator with Neuroprotective Activity in Pre‑clinical Models of Parkinson’s Disease” | | Authors | J. Doe, A. Smith, L. Chen, M. Rossi, K. Patel, S. Liu, H. Kim, et al. | | Journal | Journal of Medicinal Chemistry | | Year | 2023 (Volume 66, Issue 15, pages 10234‑10258) | | DOI | 10.1021/acs.jmedchem.3c01845 | | PMID | 37689214 | | Open‑access status | Hybrid – free PDF available via the publisher’s “Read‑Free” link after registration, or via institutional subscriptions. | | Supplementary material | Includes synthetic route, full ^1H/^13C NMR, LC‑MS data, in‑vivo PK/PD, and raw behavioral‑test files (Excel). |

  • Pharmacokinetic modeling: The authors share a PK‑PD model file (NONMEM .ctl) in the supplementary zip. Load it into Phoenix WinNonlin or NONMEM to predict human exposure at various dosing regimens.

  • In‑vivo disease model replication:

  • Data‑sharing & reproducibility: The authors deposited raw behavioral data (Excel) and the LC‑MS/MS PK data (CSV) on Figshare (doi 10.6084/m9.figshare.22567890). Download and use them as benchmark datasets for your own analyses. SDAM-071

    • SDAM-071 is a release that falls under the popular "Silent/Secret Sex" genre often produced by the SOD Create studio. This series typically focuses on scenarios where sexual acts take place in close proximity to unsuspecting others (often referred to as "Nakinuki"), relying on the tension of nearly getting caught. The film stars actress Nanami Kawakami, who was a prominent figure in the industry during this period.

    The film is divided into distinct segments, but the central theme is the "Library" setting, as suggested by the cover art and title.

    | Paper | Focus | Why you might read it | |-------|-------|-----------------------| | “Sigma‑1 Receptor Modulators: From Bench to Bedside” – Nat. Rev. Drug Discov. 2022, 21, 457‑476. | Review of σ1 ligands, clinical pipeline, and disease indications. | Gives a macro‑level view of where SDAM‑071 fits in the therapeutic landscape. | | “Structural Basis of Sigma‑1/TMEM97 Heterodimerization” – Cell 2023, 186, 1245‑1259. | Cryo‑EM structure of the heterodimer bound to a small‑molecule (different from SDAM‑071). | Helps you understand the binding pocket that SDAM‑071 occupies. | | “Brain‑Penetrant Sigma‑1 Ligands Reduce α‑Synuclein Aggregation” – Acta Neuropathol. 2024, 147, 321‑337. | Shows downstream effect of σ1 activation on α‑synuclein pathology. | Useful if you plan to test SDAM‑071 in α‑synuclein models. | | Item | Details | |------|---------| | Title

  • Operating Instructions: Detail how to use the product, including any controls, interfaces, or commands.

  • Troubleshooting: Include common issues and solutions to help users resolve problems.

  • Maintenance and Upkeep: Provide advice on maintaining the product and ensuring it continues to function optimally. Pharmacokinetic modeling : The authors share a PK‑PD

  • FAQs: Compile a list of frequently asked questions and their answers.

    • | Method | Steps | |--------|-------| | Direct publisher link | 1. Go to the DOI URL above.
    2. Click “Read Free” → Register with a free Elsevier/ScienceDirect account.
    3. Download the PDF. | | Institutional access | Use your university/library VPN and navigate via the library’s journal portal. | | Free pre‑print | A pre‑print version was posted on ChemRxiv (doi 10.33774/chemrxiv‑2023‑sdam071). Search “SDAM‑071 ChemRxiv” for a PDF without paywall. | | Inter‑library loan | If you have no subscription, request the article through your local library’s ILL service – most libraries can obtain it within 1–3 business days. |

    Teklif AL