Once installed correctly:
The CH382L uses memory-mapped I/O, not traditional ISA-style I/O ports. Some legacy software (like old DOS-based parallel programmers) assumes direct I/O port access (0x378, 0x278). You may need UserPort, GiveIO, or InpOut32 to grant access. However, modern Windows 10 security blocks this. Consider running such software in a Windows XP virtual machine with PCIe passthrough. wch ch382l driver windows 10
For specialized uses (e.g., EPP/ECP modes for hardware programmers), some users replace the WCH driver with libusb-win32 via Zadig tool. This is not recommended for standard printer use. Once installed correctly: The CH382L uses memory-mapped I/O,